Nick Lane





  1. Lane, Nick. The Vital Question. Why is life the way it is? (to be published by WW Norton/Profile in April 2015)

  2. Lane, Nick. Life Ascending: The Ten Great Inventions of Evolution. WW Norton/Profile, 2009

  3. Lane, Nick. Power, Sex, Suicide: Mitochondria and the Meaning of Life. OUP, Oxford, 2005

  4. Lane, Nick. Oxygen: The Molecule that made the World. OUP, Oxford, 2002


Edited Books

  1. Fuller BJ, Lane N, Benson EE (Eds.) Life in the Frozen State. CRC Press, Boca Raton, 2004

  2. Lane N, Allen JF, Martin WF, Raven JA (Eds). Energy Transduction and Genome Function - An Evolutionary Synthesis. Special Issue, Philosophical Transactions of the Royal Society of London, 2013


Peer-reviewed Articles

View citations on Google Scholar

  1. Lane N, Martin W, Eukaryotes really are special, and mitochondria are why. PNAS doi: 10.1073/pnas.1509237112; 2015.

  2. Lane N. The unseen world: reflections on Leeuwenhoek (1677) ‘Concerning little animals’. Phil Trans Roy Soc Lond B. 370: 20140344; 2015.

  3. Kuijper B, Lane N, Pomiankowski A. Can paternal leakage maintain sexually antagonistic polymorphism in the cytoplasm? Journal of Evolutionary Biology 28: 468–480; 2015

  4. Herschy B, Whicher A, Camprubi E, Watson C, Dartnell L, Ward J, Evans JRG, Lane N. An origin-of-life reactor to simulate alkaline hydrothermal vents. Journal of Molecular Evolution 79: 213-227; 2014.

  5. Sojo V, Pomiankowski A, Lane N. A bioenergetic basis for membrane divergence in archaea and bacteria. PLOS Biology. 12: e1001926; 2014.

  6. Martin W, Sousa FL, Lane N. Energy at life's origin. Science 344: 1092-93; 2014

  7. Lane N. (2013). Bioenergetic constraints on the evolution of complex life. In P. J. Keeling, E. V. Koonin (Eds.). The Origin and Evolution of Eukaryotes. Cold Spring Harbor Perspectives in Biology. doi: 10.1101/cshperspect.a015982; 2014.

  8. Hadjivasiliou Z, Lane N, Seymour R, Pomiankowski A. Dynamics of mitochondrial inheritance in the evolution of binary mating types and two sexes. Proc Roy Soc B 280: 20131920; 2013.

  9. Sousa FL, Thiergart T, Landan G, Nelson-Sathi S, Pereira IAC, Allen JF, Lane N, Martin WF. Early bioenergetic evolution. Phil Trans Roy Soc Lond B. 368: 20130088.; 2013.

  10. Lane N, Martin WF, Raven JA, Allen JF. Energy, genes and evolution: Introduction to an evolutionary synthesis. Phil Trans Roy Soc Lond B. 368: 20120253.; 2013.

  11. Lane N, Martin WF. The origin of membrane bioenergetics. Cell 151: 1406-16; 2012

  12. Lane N. The problem with mixing mitochondria. Cell 151: 246-248; 2012

  13. Pesole G, Allen JF, Lane N, Martin W, Rand DM, Schatz G, Saccone C. The neglected genome. EMBO Reports 13: 473-4; 2012.

  14. Lane N. Thermodynamics, formamide, and the origin of life. Physics of Life Reviews 9: 106-106; 2012.

  15. Hadjivasiliou Z, Pomiankowski A, Seymour R, Lane N. Selection for mitonuclear co-adaptation could favour the evolution of two sexes. Proc Roy Soc B279: 1865-1872; 2012.

  16. Lane N. The costs of breathing. Science 334: 184-185; 2011.

  17. Lane N. Mitonuclear match: optimizing fitness and fertility over generations drives aging within generations. BioEssays 33: 860-869; 2011.

  18. McInerney JO, Martin W, Koonin EV, Allen JF, Galperin MY, Lane N, Archibald JM, Embley TM. Planctomycetes and eukaryotes: a case of analogy not homology. BioEssays 33: 810-7; 2011.

  19. Kitazoe Y, Kishino H, Hasegawa M, Matsui A, Lane N, Tanaka M. Stability of mitochondrial membrane proteins in terrestrial vertebrates predicts aerobic capacity and longevity. Genome Biol. Evol 3: 1233-1244; 2011.

  20. Lane N. The evolution of oxidative stress. In: Principles of Free Radical Biomedicine. Eds. Pantopoulos K, Schipper H. Nova Science Publications Inc, Hauppauge, NY, 2011.

  21. Lane N. Energetics and genetics across the prokaryote-eukaryote divide. Biology Direct 6: 35; 2011.

  22. Lane N. Plastids, genomes and the probability of gene transfer. Genome Biol Evol 3: 372-374; 2011.

  23. Lane N, Martin W. The energetics of genome complexity. Nature 467: 929-934; 2010.

  24. Lane N. Why are cells powered by proton gradients? Nature Education 3(9):18; 2010.

  25. Lane N. Chance or necessity? Bioenergetics and the probability of life. J Cosmol 10: 7; 2010.

  26. Lane N. Intelligent non-design and the origins of life. J Cosmol 8: 16; 2010.

  27. Lane N, Allen JF, Martin W. How did LUCA make a living? Chemiosmosis in the origin of life. Bioessays 32: 271-280; 2010.

  28. Lane N. Low variability on the W chromosome in birds is more likely to reflect selection on mitochondrial genes. Heredity 100: 444-5; 2008.

  29. Lane, N. Mitochondria: Key to complexity. In: Martin, W (ed), Origins of Mitochondria and Hydrogenosomes. Springer, Heidelberg, Germany 2006.

  30. Lane N. The future of cryobiology. In: Life in the Frozen State, Eds: Fuller B, Lane NJ, Benson EE. Taylor and Francis, London, 2004.

  31. Lane N. A unifying view of aging and disease: the double agent theory. J Theoret Biol 22: 531-540; 2003.

  32. Lane N. Medical constraints on the quantum mind. Review article. J Roy Soc Med 93: 571-575; 2000

  33. Lane N, Allen K. Hyponatraemia after orthopaedic surgery: Ignorance of the effects of hyponatraemia after surgery is widespread - and damaging. Editorial. BMJ 318: 1363-1364; 1999; discussion in BMJ 319: 514-516; 1999

  34. Lane N. Common sense, nonsense and statistics. Personal paper. J Roy Soc Med 92: 202-205; 1999; reprinted with commentary in Contemp Rev Obstet Gynaecol Sept 1999; 149-153

  35. Lane, N. Thrombolytic therapy for acute ischaemic stroke. Letter. Lancet 350: 1475-1476; 1997

  36. Lane NJ, Thorniley MS, Manek S, Fuller BJ, Green CJ. The effect of mannitol and polyethylene glycol on the action of frusemide during renal storage and transplantation. Transplantation 62: 575-582; 1996

  37. Lane NJ, Thorniley MS, Manek S, Fuller BJ, Green CJ. Hemoglobin oxygenation kinetics and secondary ischemia in renal transplantation. Transplantation 61: 689-696; 1996

  38. Thorniley MS, Lane NJ, Simpkin S, Fuller BJ, Jenabzadeh MZ, Green CJ. Monitoring of mitochondrial NADH levels by surface fluorometry as an indication of ischaemia during hepatic and renal transplantation. In Oxygen Transport to Tissue Vol XVII (Eds Ince C, Kesecioglu J, Trelci I, Apkir K); Plenum Press, New York, 1996, pp 431-444.

  39. Lane NJ, Thorniley MS, Manek S, Fuller BJ, Green CJ. Iron chelation, respiratory chain function and tubular necrosis in renal transplantation. Biochem Soc Trans 23: 524S; 1995.

  40. Lane NJ, Thorniley MS, Manek S, Fuller BJ, Green CJ. Iron chelation and respiratory chain function in vivo in renal ischaemia-reperfusion injury. Clin Sci 89: 31P; 1995

  41. Lane NJ, Thorniley MS, Manek S, Fuller BJ, Green CJ. Inhibition of leukotriene B4 synthesis does not prevent development of acute renal failure following storage and transplantation. Transplantation 58: 1303-1308; 1994

  42. Lane NJ, Thorniley MS, Manek S, Green CJ. Vascular congestion does not correlate with mitochondrial dysfunction following renal transplantation. J Pathol 172 (suppl): 138A; 1994

  43. Thorniley MS, Lane NJ, Manek S, Green CJ. Non-invasive measurement of respiratory chain dysfunction following hypothermic renal storage and transplantation. Kidney Int 45: 1489-1496; 1994

  44. Thorniley MS, Lane NJ, Manek S, Green CJ. Non-invasive monitoring of renal haemoglobin oxygenation kinetics following hypothermic storage and transplantation. Biochem Soc Trans 21: 501S; 1993

  45. Thorniley MS, Lane NJ, Green CJ. Non-invasive monitoring of renal tissue oxygen sufficiency for transplantation. Clin Sci 85: 22P; 1993

  46. Thorniley MS, Lane NJ, Manek S, Green CJ. In vivo monitoring of respiratory chain dysfunction following renal storage and transplantation. Biochem Soc Trans 21: 500S; 1993

  47. Gower JD, Lane NJ, Goddard JG, Manek S, Ambrose IJ, Green CJ. Ebselen: Antioxidant capacity in renal preservation. Biochem Pharmacol 43: 2341-2348; 1992

  48. Toffa SEK, Fuller BJ, Gower JD, Lane NJ, Green CJ. Oxygen-free reperfusion of ischaemic kidneys. Int J Rad Biol 62: 116; 1992


Feature articles

  1. Lane N. Life's X factor. The Scientist, August 4th 2015

  2. Lane N. Life: Inevitable or fluke? New Scientist, 21 June 2012.

  3. Lane N. Genesis revisited. New Scientist, 7 August: 36-39; 2010.

  4. Lane N. Life's a gas. New Scientist, 6 February: 36-39; 2010.

  5. Lane N. On the origin of barcodes. Nature 462: 272-274; 2009.

  6. Lane N. Cradle of life. New Scientist, October 17: 38-42; 2009.

  7. Lane N. Why sex is worth losing your head for. New Scientist 13 June: 40-43; 2009.

  8. Lane N. The furnace within. New Scientist 07 February: 42-45; 2009.

  9. Lane N. New light on medicine. Revised and updated for Scientific American special issue on cancer, July 2008.

  10. Lane N. One baby, two mums. New Scientist, 7 June: 38-41; 2008.

  11. Lane N. Origins of Death. Nature 453: 583-585; 2008.

  12. Lane N. What's in the rising tide? Nature 449: 778-780; 2007.

  13. Lane N. Reading the book of death. Nature 448: 122-125; 2007.

  14. Lane N. Power games. Nature 443: 901-903; 2006.

  15. Lane N. Plugging the mitochondrial leak. The Scientist 20: 34; 2006.

  16. Lane N. What can’t bacteria do? Nature 441: 274-7; 2006.

  17. Lane N. Powerhouse of disease. Nature 440: 600-2; 2006.

  18. Lane N. New light on medicine. Scientific American, January 2003

  19. Lane N. Born to the purple: the story of porphyria. Scientific American online, December 2002

  20. Lane N. The Big O. New Scientist, December 14, 2002

  21. Lane N. Blood ties. The Sciences. New York Academy of Sciences. Sept/Oct pp 24-29, 1998; discussion Jan/Feb 19

  22. Lane N. Radical Problems in Renal Transplantation. Biologist 1996; 43: 110-113